Ligandrol LGD-4033 (MYO LGD) SARMs Review: Side Effects, Dosage, Before and After Results

LGD-4033 is a remarkable SARM (selective androgen receptor modulator) that enhances athletic performance and produces substantial muscle gains. Coupling it with regular exercise can achieve up to 4 kg of lean muscle in just 30 days.

Key Takeaway

  • Beginners are recommended to take 2mg per day for eight weeks, while advanced users are advised to take between 15-20 mg daily.
  • After being developed by Ligand Pharmaceuticals, LGD-4033 was later studied by Viking Therapeutics for potential use in treating various medical conditions.
  • Ligandrol interacts with muscle receptors, enhancing growth, repair, oxygenation, and nutrient absorption.

According to Doctor Thomas O’Connor, MD LGD-4033 directly enhances lean muscle mass and strength in targeted tissues without causing hair loss or prostate problems. This SARM offers numerous benefits, such as elevated testosterone levels, improved focus, increased energy, enhanced endurance, and stronger muscles and bones. 

It also defends against muscle damage and facilitates effective fat reduction. You might encounter initial testosterone suppression, migraines, and severe dry mouth, lasting around 3 months. This blog post will discuss Ligandrol benefits, side effects, recommended cycles, appropriate dosage, and achievable outcomes.

What is MYO LGD 4033? 

What is MYO LGD 4033?

LGD-4033, or Ligandrol or MYO-LGD, is a modern workout aid designed to enhance muscle growth and boost sports performance. It belongs to a class of supplements known as SARMs. These dietary supplements imitate male hormones in specific body regions, leaving others untouched. MYO-LGD can help you get stronger and fitter by targeting specific muscles and leaving other parts untouched.

This selective androgen receptor modulator was originally developed by Ligand Pharmaceuticals in the US and patented in 2009. 2013 the first human trial showed increased lean body mass without adding fat mass. 

Viking Therapeutics acquired the rights and, in 2018 conducted a trial on elderly hip fracture patients, demonstrating improved lean muscle mass and mobility. Ligandrol has been studied for cancer-related weight loss, prostate issues, and more.

LGD-4033 has a chemical formula of C14H12F6N2O. Its molecule structure is composed of 36 bonds, 24 non-H bonds, 7 multiple bonds, 2 rotatable bonds, 1 triple bond, 6 aromatic bonds, 1 five-membered ring, 1 six-membered ring, 1 tertiary amine (aromatic), 1 nitrile (aromatic), 1 hydroxyl group, 1 secondary alcohol, and 1 Pyrrolidine.

How Does Ligandrol Work?

LGD-4033 boosts your muscles and strength by talking to special receptors in your muscles. These receptors are like tiny bosses that tell your muscles to grow and fix themselves. Users of this Sarm will feel anabolic effects sooner than usual because to MYO LGD’s rapid binding capabilities.

MYO-LGD from Savage Line Labs gives your muscles a high-five, making them grab more oxygen and super-nutrients. This teamwork helps your muscles become superstars, working harder and healing quicker. 

Five Ingredients of MYO LGD

LGD-4033 is made up of five ingredients which are mentioned below:

1. LGD

LGD sparks lean muscle mass and recovery by supercharging protein synthesis and nitrogen retention. Its targeted approach minimizes unwanted side effects commonly associated with traditional anabolic steroids.

2. Caffeine

Anhydrous caffeine provides a healthy source of energy and stamina. It enhances receptor function, improving brain performance and reducing stress.

3. Schisandra Chinensis

This element elevates endurance and overall performance, benefiting sensual health and energy levels.

4. Beetroot Extract

It supports better testosterone levels and overall body function and is essential for stamina and immune system enhancement.

5. Cholecalciferol

A vital vitamin D source that boosts brain and body function while aiding in weight loss and promoting stamina.

Ligandrol Use Cases

Ligandrol is a powerhouse in bodybuilding, promoting muscle growth while averting muscle breakdown. It facilitates muscle development, yielding more promising outcomes from your workouts. This compound enhances muscle strength, diminishes body fat mass, thwarts muscle loss, improves endurance, and accelerates recovery times.

LGD 4033 Cycle & Dosage 

LGD 4033 Cycle & Dosage

Below we have discussed the cycles and dosages of beginner & advanced-level muscle builders:

LGD 4033 Cycle & Dosage for Beginners

A low dose of 2 mg daily for eight weeks is recommended. Placebo research suggests that visible muscle growth is stimulated even at these modest levels. This approach optimizes your potential gains and minimizes the risk of unwanted side effects. 

By sticking to this conservative dosage, you can enjoy impressive gains in muscle strength and muscle mass, skipping the need for post-cycle therapy (PCT). This cautious method is advantageous due to the minimal Androgen suppression in these low-dose cycles.

LGD 4033 Cycle & Dosage for Advanced

The recommended range is between 15 to 20 mg per day. Experts suggest an advanced level muscle builder of 20 mg daily. At 20 mg, testosterone reduction and water retention increase significantly, often outweighing the benefits. Most of that, a 15-20 mg dose for a 6-8 week cycle and post-cycle therapy offers a balanced approach.

LGD 4033 Stacks 

By pairing LGD 4033 with SARMs like Testolone (RAD 140), you boost protein synthesis, enhance physical function, and achieve an anabolic steroid’s potency. For bulking, a favourite stack includes LGD 4033 and Ostarine. 

This combo results in lean mass gains without excess fat mass. A cutting stack features LGD 4033 and Cardarine, preventing muscle wasting during a calorie deficit. The LGD 4033 and Andarine S4 receptor stack works well for simultaneous muscle gain and fat loss.

Ligandrol Cycle and Dosage for Women

The MYO-LGD cycle for women’s bodybuilding usually lasts 6-10 weeks, based on experience. Women should take half the dose of men, not exceeding 8 weeks. The right Ligandrol dose is 2.5 – 5 mg daily.

Ligandrol Benefits 

Here are five potential benefits that have been suggested based on preliminary research:

1. Muscle Growth and Strength

Ligandrol stimulates muscle mass by binding to androgen receptors in muscle tissues, promoting anabolic (muscle-building) effects. It can increase muscle mass, strength, and overall physical performance.

2. Bone Health

Viking Therapeutics research suggests that Ligandrol may positively impact bone health by increasing bone mineral density. It could benefit individuals with conditions such as osteoporosis.

3. Fat Loss

Ligandrol primarily enhances muscle mass, and intriguing research also hints at its potential for supporting fat loss. This effect could be attributed to increased muscle mass and a higher metabolic rate. If you are considering cutting SARMs, this is one of the best option.

4. Endurance and Recovery

Anecdotal reports suggest that Ligandrol may enhance endurance and improve recovery after intense workouts. It could be attributed to its potential ability to increase muscle mass and promote tissue repair.

5. Hormone Regulation

Unlike regular anabolic steroids that can upset natural hormone equilibrium, Ligandrol precisely targets androgen receptors in muscles and bones. This selective binding could reduce the risk of unwanted hormonal side effects.

LGD 4033 Before & After Results

LGD 4033 Before & After Results

40% of users experienced positive outcomes with MYO-LGD for their bodybuilding objectives, showcasing enhanced strength and visible muscle growth. The remaining group stopped using LGD 4033 due to the side effects they encountered. 

MYO-LGD results vary individually, shaped by workout patterns and dietary preferences. Some individuals see rapid improvements if they target their muscles effectively during workouts. In the initial stages, users often enjoy a substantial strength surge, enhanced muscle mass and noticeable shifts in body composition. 

Many have achieved positive results for a safer cycling experience by beginning with a modest 5 mg dose for 8 weeks. This approach minimizes typical side effects such as reduced libido, testosterone decline, and mood swings. In general, an 8-week cycle of LGD 4033 could lead to gains of up to 34 lbs in muscle and fat.

Does Ligandrol Affect Testosterone Production? 

Yes, Ligandrol does affect testosterone production. This selective androgen receptor modulator has gained popularity for its ability to boost testosterone levels and regulate estrogen production. Many individuals utilize Ligandrol to enhance their testosterone levels and address mental health concerns.

LGD 4033 Side Effects

LGD 4033 Side Effects

Five potential side effects associated with LGD-4033 include:

1. Testosterone Suppression

MYO-LGD can suppress natural testosterone production. It could lower testosterone, causing reduced libido, fatigue, and mood shifts.

2. Hormonal Imbalance

Since LGD-4033 affects androgen receptors, it can disrupt the hormonal balance in the body. It might lead to unpredictable changes in mood, energy levels, high blood pressure, and overall well-being.

3. Liver Enzyme Changes

Rheumatology & Arthritis Research studies have suggested that LGD-4033 might cause mild elevations in liver enzymes. These changes usually revert after stopping the compound and are generally less severe than those linked to certain oral steroids.

4. Hair Loss

MYO-LGD could speed up hair loss in those genetically prone to male pattern baldness. It is due to its potential to affect androgen receptors on the scalp.

5. Other Androgenic Side Effects

Like traditional anabolic steroids, LGD-4033 can potentially cause androgenic side effects such as acne, oily skin, and increased body hair growth.

Who is Ligandrol Suitable for?

Ligandrol offers a rapid strength and muscle boost without conventional steroids. LGD-4033 appeals to those focused on improving their physique for aesthetic purposes. That’s why, it is considered one of the best bulking SARMs by pro bodybuilders. If you aim for rapid and lasting results, Ligandrol might be a viable choice. 

Moreover, MYO-LGD can enhance the bone structure for those worried about workout injuries, potentially reducing workout risks. These selective androgen receptor modulators are especially fitting for individuals engaged in bodybuilding and other power sports. Professional athletes must avoid Ligandrol because of its potent doping effects, making it inappropriate for competitive sports.

Avoid using this SARM for gaining muscle or treating conditions like prostate cancer if you have high blood pressure or a cardiac condition.



LGD 4033 is illegal in Canada for human use when intended for performance gains. It is due to serious health risks like heart attacks, strokes, and liver damage. Despite its anabolic, muscle-building effects, athletes avoid abusing it, as its dangers outweigh the potential benefits.

Does LGD 4033 Need a PCT?

LGD 4033 does not require a PCT, as with anabolic steroids. LGD 4033 stands out as a unique SARM, offering a fresh approach distinct from conventional steroids. SARMs like MYO-LGD target specific androgen receptors in the body, focusing on muscle and bone tissues without impacting other organs. Unlike anabolic steroids, LGD 4033 doesn’t strongly suppress natural testosterone production, making a PCT unnecessary.

Where to Buy LGD 4033 in Canada?

You can buy LGD 4033 online in Canada. Trusted sellers with testing and quality guarantees are essential. Reputable fitness sites and some online stores might have them. Ensure safety by researching before purchasing selective androgen receptor modulators. For a dependable choice, consider We offer a reliable option with quality guarantees and testing.

When Are the First Results of Ligandrol Visible? 

Within 4 weeks, the results of Ligandrol become visible. This cycle continues for more than 4 weeks. Ligandrol’s rapid visibility boost stems from its unique capacity to target muscle receptors, amplifying their growth potential precisely. The initial gains include increased strength and endurance, making workouts more effective.

LGD 4033 Vs RAD140 Vs Mk 677

In the battle of LGD 4033 vs. RAD 140 vs. MK 677, MYO-LGD takes the lead with bigger gains and lower doses for the same results. Yet, RAD 140 offers drier and harder gains akin to a boosted Andarine. LGD 4033, RAD 140 and MK 677 aid muscle repair and bone-building research for age-related frailty and muscle loss.

LGD 4033 Vs LGD 3033: Which One is Better?

LGD-4033 is better due to its comprehensive health benefits. These performance enhancing supplements enhance muscle mass, reduce fat mass, increase bone density, speed recovery, and improve stamina. It even raises HDL cholesterol levels.

You can notice significant gains and improve physical function in not time. This investigational drugs maintain lean body mass while elevating strength, endurance, and overall performance. LGD-3033 mainly focuses on lean muscle mass and strength, but LGD-4033 offers a broader range of health improvements.

Final Thoughts

Ligandrol is a cutting-edge workout aid that supports muscle growth and performance enhancement. As selective androgen receptor modulators, they target specific muscles, leaving other areas unaffected. By binding to muscle receptors, MYO-LGD promotes muscle growth, bone density, fat loss, endurance, and recovery. 

While providing many advantages, it’s vital to acknowledge potential side effects like testosterone reduction and hormonal imbalance. LGD-4033 is ideal for those aiming for quick strength and physique enhancement. 

Inadvisable for elite athletes due to its potential implications for doping. Noticeable results in just 4 weeks. MYO-LGD shines among other compounds, offering a range of exceptional health benefits.


  • Shehzad Basaria, Lauren Collins, E. Lichar Dillon, Katie Orwoll, Thomas W. Storer, Renee Miciek, Jagadish Ulloor, Anqi Zhang (Mar 28, 2010) The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men
  • Brett W. Sadowski (Sep 9, 2019) Top 5 Things to Know about LGD-4033
  • Hansson A, Knych H, Stanley S, Berndtson E, Jackson L, Bondesson U (February 7, 2018) Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites
  • Geldof L, Pozo OJ, Lootens L, Morthier W (February 19, 2017) In vitro metabolism study of a black market product containing SARM LGD-4033
  • Cox HD, Eichner D (May 11, 2016) Detection of LGD-4033 and its metabolites in athlete urine samples
  • Thomas D. Cardaci, Steven B. Machek, Dylan T. Wilburn, Jeffery L. Heileson, Dillon R. Harris, Harry P. Cintineo, Darryn S. Willoughby (October 27, 2022) LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report

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